WISP-1 promotes VEGF-C-dependent lymphangiogenesis by inhibiting miR-300 in human oral squamous cell carcinoma cells
Identifieur interne : 000928 ( Main/Exploration ); précédent : 000927; suivant : 000929WISP-1 promotes VEGF-C-dependent lymphangiogenesis by inhibiting miR-300 in human oral squamous cell carcinoma cells
Auteurs : Ching-Chia Lin [Taïwan] ; Po-Chun Chen [Taïwan] ; Ming-Yu Lein [Taïwan] ; Ching-Wen Tsao [Taïwan] ; Chiu-Chen Huang [Taïwan] ; Shih-Wei Wang [Taïwan] ; Chih-Hsin Tang [Taïwan] ; Kwong-Chung Tung [Taïwan]Source :
- Oncotarget [ 1949-2553 ] ; 2016.
Abstract
Oral squamous cell carcinoma (OSCC), which accounts for nearly 90% of head and neck cancers, is characterized by a poor prognosis and a low survival rate. Vascular endothelial growth factor-C (VEGF-C) has been implicated in lymphangiogenesis and is correlated with cancer metastasis. WNT1-inducible signaling pathway protein-1 (WISP)-1/CCN4 is an extracellular matrix-related protein that belongs to the CCN family and stimulates many biological functions. Our previous studies showed that WISP-1 plays an important role in OSCC migration and angiogenesis. However, the effect of WISP-1 on VEGF-C regulation and lymphangiogenesis in OSCC is poorly understood. Here, we showed a correlation between WISP-1 and VEGF-C in tissue specimens from patients with OSCC. To examine the lymphangiogenic effect of WISP-1, we used human lymphatic endothelial cells (LECs) to mimic lymphatic vessel formation. The results showed that conditioned media from WISP-1-treated OSCC cells promoted tube formation and cell migration in LECs. We also found that WISP-1-induced VEGF-C is mediated via the integrin αvβ3/integrin-linked kinase (ILK)/Akt signaling pathway. In addition, the expression of microRNA-300 (miR-300) was inhibited by WISP-1 via the integrin αvβ3/ILK/Akt cascade. Collectively, these results reveal the detailed mechanism by which WISP-1 promotes lymphangiogenesis via upregulation of VEGF-C expression in OSCC. Therefore, WISP-1 could serve as therapeutic target to prevent metastasis and lymphangiogenesis in OSCC.
Url:
DOI: 10.18632/oncotarget.7014
PubMed: 26824419
PubMed Central: 4891098
Affiliations:
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Chih Hsin" sort="Tang, Chih Hsin" uniqKey="Tang C" first="Chih-Hsin" last="Tang">Chih-Hsin Tang</name><affiliation wicri:level="1"><nlm:aff id="A2"> Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea> Graduate Institute of Basic Medical Science, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A7"> Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea> Department of Pharmacology, School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8"> Department of Biotechnology, College of Health Science, Asia University, Taichung, Taiwan</nlm:aff><country 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cells</title><author><name sortKey="Lin, Ching Chia" sort="Lin, Ching Chia" uniqKey="Lin C" first="Ching-Chia" last="Lin">Ching-Chia Lin</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea> Department of Veterinary Medicine, National Chung Hsing University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Po Chun" sort="Chen, Po Chun" uniqKey="Chen P" first="Po-Chun" last="Chen">Po-Chun Chen</name><affiliation wicri:level="1"><nlm:aff id="A2"> Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea> Graduate Institute of Basic Medical Science, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3"> Department of Medical Research, Chung Shan Medical University Hospital, Chung Shan Medical University, Taichung, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea> Department of Medical Research, Chung Shan Medical University Hospital, Chung Shan Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Lein, Ming Yu" sort="Lein, Ming Yu" uniqKey="Lein M" first="Ming-Yu" last="Lein">Ming-Yu Lein</name><affiliation wicri:level="1"><nlm:aff id="A2"> Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea> Graduate Institute of Basic Medical Science, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4"> Division of Hematology and Oncology, Department of Internal 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id="A5"> Sing Wang Animal Hospital, Taichung, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea> Sing Wang Animal Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Shih Wei" sort="Wang, Shih Wei" uniqKey="Wang S" first="Shih-Wei" last="Wang">Shih-Wei Wang</name><affiliation wicri:level="1"><nlm:aff id="A6"> Department of Medicine, Mackay Medical College, New Taipei City, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea> Department of Medicine, Mackay Medical College, New Taipei City</wicri:regionArea><wicri:noRegion>New Taipei City</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Chih Hsin" sort="Tang, Chih Hsin" uniqKey="Tang C" first="Chih-Hsin" last="Tang">Chih-Hsin Tang</name><affiliation wicri:level="1"><nlm:aff id="A2"> Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea> Graduate Institute of Basic Medical Science, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A7"> Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea> Department of Pharmacology, School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8"> Department of Biotechnology, College of Health Science, Asia University, Taichung, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea> Department of Biotechnology, College of Health Science, Asia University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Tung, Kwong Chung" sort="Tung, Kwong Chung" uniqKey="Tung K" first="Kwong-Chung" last="Tung">Kwong-Chung Tung</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea> Department of Veterinary Medicine, National Chung Hsing University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oncotarget</title><idno type="eISSN">1949-2553</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Oral squamous cell carcinoma (OSCC), which accounts for nearly 90% of head and neck cancers, is characterized by a poor prognosis and a low survival rate. Vascular endothelial growth factor-C (VEGF-C) has been implicated in lymphangiogenesis and is correlated with cancer metastasis. WNT1-inducible signaling pathway protein-1 (WISP)-1/CCN4 is an extracellular matrix-related protein that belongs to the CCN family and stimulates many biological functions. Our previous studies showed that WISP-1 plays an important role in OSCC migration and angiogenesis. However, the effect of WISP-1 on VEGF-C regulation and lymphangiogenesis in OSCC is poorly understood. Here, we showed a correlation between WISP-1 and VEGF-C in tissue specimens from patients with OSCC. To examine the lymphangiogenic effect of WISP-1, we used human lymphatic endothelial cells (LECs) to mimic lymphatic vessel formation. The results showed that conditioned media from WISP-1-treated OSCC cells promoted tube formation and cell migration in LECs. We also found that WISP-1-induced VEGF-C is mediated via the integrin αvβ3/integrin-linked kinase (ILK)/Akt signaling pathway. In addition, the expression of microRNA-300 (miR-300) was inhibited by WISP-1 via the integrin αvβ3/ILK/Akt cascade. Collectively, these results reveal the detailed mechanism by which WISP-1 promotes lymphangiogenesis via upregulation of VEGF-C expression in OSCC. Therefore, WISP-1 could serve as therapeutic target to prevent metastasis and lymphangiogenesis in OSCC.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Johnson, Nw" uniqKey="Johnson N">NW Johnson</name></author><author><name sortKey="Jayasekara, P" uniqKey="Jayasekara P">P Jayasekara</name></author><author><name sortKey="Amarasinghe, Aa" uniqKey="Amarasinghe A">AA Amarasinghe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, Nw" uniqKey="Johnson N">NW Johnson</name></author><author><name sortKey="Warnakulasuriya, S" uniqKey="Warnakulasuriya S">S Warnakulasuriya</name></author><author><name sortKey="Gupta, Pc" uniqKey="Gupta P">PC Gupta</name></author><author><name sortKey="Dimba, E" uniqKey="Dimba E">E Dimba</name></author><author><name sortKey="Chindia, M" uniqKey="Chindia M">M Chindia</name></author><author><name sortKey="Otoh, Ec" uniqKey="Otoh E">EC Otoh</name></author><author><name 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Chiu Chen" sort="Huang, Chiu Chen" uniqKey="Huang C" first="Chiu-Chen" last="Huang">Chiu-Chen Huang</name><name sortKey="Lein, Ming Yu" sort="Lein, Ming Yu" uniqKey="Lein M" first="Ming-Yu" last="Lein">Ming-Yu Lein</name><name sortKey="Lein, Ming Yu" sort="Lein, Ming Yu" uniqKey="Lein M" first="Ming-Yu" last="Lein">Ming-Yu Lein</name><name sortKey="Tang, Chih Hsin" sort="Tang, Chih Hsin" uniqKey="Tang C" first="Chih-Hsin" last="Tang">Chih-Hsin Tang</name><name sortKey="Tang, Chih Hsin" sort="Tang, Chih Hsin" uniqKey="Tang C" first="Chih-Hsin" last="Tang">Chih-Hsin Tang</name><name sortKey="Tang, Chih Hsin" sort="Tang, Chih Hsin" uniqKey="Tang C" first="Chih-Hsin" last="Tang">Chih-Hsin Tang</name><name sortKey="Tsao, Ching Wen" sort="Tsao, Ching Wen" uniqKey="Tsao C" first="Ching-Wen" last="Tsao">Ching-Wen Tsao</name><name sortKey="Tung, Kwong Chung" sort="Tung, Kwong Chung" uniqKey="Tung K" first="Kwong-Chung" last="Tung">Kwong-Chung Tung</name><name sortKey="Wang, Shih Wei" sort="Wang, Shih Wei" uniqKey="Wang S" first="Shih-Wei" last="Wang">Shih-Wei Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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